Scotland v England
DAM Health Stadium, Edinburgh
Saturday, 26 March, 2022		 Referee: Joy Neville (IRFU)
Assistant Referee 1: Aurélie Groizeleau (FFR)
Assistant Referee 2: Maria Beatrice Benvenuti (FIR)
TMO: Matteo Liperini (FIR)
Ireland v Wales
RDS Stadium, Dublin
Saturday, 26 March, 2022		 Referee: Kat Roche (USAR)
Assistant Referee 1: Hollie Davidson (SRU)
Assistant Referee 2: Nikki O'Donnell (RFU)
TMO: Claire Hodnett (RFU)
France v Italy
Stade des Alpes, Grenoble
Sunday, 27 March, 2022		 Referee: Sara Cox (RFU)
Assistant Referee 1: Aimee Barrett-Theron (SARU)
Assistant Referee 2: Precious Pazani (ZIM)
TMO: Chris Assmus (RC)
France v Ireland
Stade Ernest Wallon, Toulouse
Saturday, 2 April, 2022		 Referee: Aimee Barrett-Theron (SARU)
Assistant Referee 1: Clara Munarini (FIR)
Assistant Referee 2: Precious Pazani (ZIM)
TMO: Ian Tempest (RFU)
Wales v Scotland
Cardiff Arms Park, Cardiff
Saturday, 2 April, 2022		 Referee: Joy Neville (IRFU)
Assistant Referee 1: Nikki O'Donnell (RFU)
Assistant Referee 2: Katherine Ritchie (RFU)
TMO: Chris Assmus (RC)
Italy v England
Stadio Sergio Lanfranchi, Parma
Sunday, 3 April, 2022		 Referee: Hollie Davidson (SRU)
Assistant Referee 1: Doriane Domenjo (FFR)
Assistant Referee 2: Gabriel Chirnoaga (FIR)
TMO: Eric Gauzins (FFR)
England v Wales
Kingsholm Stadium, Gloucester
Saturday, 9 April, 2022		 Referee: Julianne Zussman (RC)
Assistant Referee 1: Hollie Davidson (SRU)
Assistant Referee 2: Maria Latos (GER)
TMO: Matteo Liperini (FIR)
Scotland v France
Scotstoun Stadium, Glasgow
Sunday, 10 April, 2022		 Referee: Clara Munarini (FIR)
Assistant Referee 1: Nikki O'Donnell (RFU)
Assistant Referee 2: Maria Giovanna Pacifico (FIR)
TMO: Ben Whitehouse (WRU)
Ireland v Italy
Musgrave Park, Cork
Sunday, 10 April, 2022		 Referee: Aurélie Groizeleau (FFR)
Assistant Referee 1: Doriane Domenjo (FFR)
Assistant Referee 2: Francesca Martin (WRU)
TMO: Eric Gauzins (FFR)
Wales v France
Cardiff Arms Park, Cardiff
Friday, 22 April, 2022		 Referee: Maggie Cogger-Orr (NZR) 
Assistant Referee 1: Joy Neville (IRFU)
Assistant Referee 2: Maria Beatrice Benvenuti (FIR)
TMO: Olly Hodges (IRFU)
Italy v Scotland
Stadio Sergio Lanfranchi, Parma
Saturday, 23 April, 2022		 Referee: Lauren Jenner (NZR) 
Assistant Referee 1: Sara Cox (RFU)
Assistant Referee 2: Katherine Ritchie (RFU)
TMO: Ben Whitehouse (WRU)
England v Ireland
Welford Road, Leicester
Sunday, 24 April, 2022		 Referee: Amber McLachlan (RA)
Assistant Referee 1: Aurélie Groizeleau (FFR)
Assistant Referee 2: Doriane Domenjo (FFR)
TMO: Lee Jeffrey (NZR) 
Wales v Italy
Cardiff Arms Park, Cardiff
Saturday, 30 April, 2022		 Referee: Amber McLachlan (RA)
Assistant Referee 1: Aurélie Groizeleau (FFR)
Assistant Referee 2: Maria Latos (GER)
TMO: Claire Hodnett (RFU)
France v England
Stade Jean Dauger, Bayonne
Saturday, 30 April, 2022		 Referee: Hollie Davidson (SRU)
Assistant Referee 1: Joy Neville (IRFU)
Assistant Referee 2: Maria Giovanna Pacifico (FIR)
TMO: Lee Jeffrey (NZR) 
Ireland v Scotland
Kingspan Stadium, Belfast
Saturday, 30 April, 2022		 Referee: Maggie Cogger-Orr (NZR) 
Assistant Referee 1: Clara Munarini (FIR)
Assistant Referee 2: Francesca Martin (WRU)
TMO: Ian Tempest (RFU)